Polycystic ovary syndrome and miscarriage risk: dual evidence from cohort study and Mendelian randomization.
Polycystic ovary syndrome independently linked to higher odds of miscarriage after IVF/ICSI.
Polycystic ovary syndrome and miscarriage risk: dual evidence from cohort study and Mendelian randomization.
To investigate the association between polycystic ovary syndrome (polycystic ovary syndrome) and miscarriage risk and to explore the potential causal effect.
We conducted a retrospective cohort study of 445 women who conceived via in vitro fertilization/intracytoplasmic sperm injection, comprising 191 polycystic ovary syndrome women and 254 controls.
Polycystic ovary syndrome nearly doubled the odds of miscarriage after IVF/ICSI
Subgroup analyses revealed consistent trends, though some strata lacked statistical significance.
The primary mendelian randomization analysis using the inverse-variance weighted (inverse-variance weighted) method demonstrated a significant causal effect of polycystic ovary syndrome on the risk of sporadic miscarriage (OR = 1.08, 95% CI: 1.01-1.14, p = 0.0203).
The replicated mendelian randomization analysis yielded similar effect sizes, and genetically predicted polycystic ovary syndrome liability aligned with the cohort study results.
Sensitivity analyses showed no significant heterogeneity or horizontal pleiotropy, supporting the robustness of the results.
Integrating dual evidence from clinical cohort and mendelian randomization analyses, polycystic ovary syndrome is associated with increased miscarriage risk, potentially independent of traditional risk factors.
These findings underscore the importance of early pregnancy management in women with polycystic ovary syndrome and establish a basis for future research into underlying mechanisms and potential interventions.