Genetic heritability of age at menarche and its association with early menopause in the Korean population: a…

Cohort studyJournal of Korean biological nursing science· Nov 2025

Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.

Hyerim Shin, Hye Kyung Jeon, Hae Young Yoo

Menopause & Hormone TherapyCohort studyPrognosisQ3IF 0.6

Genome-wide study identifies 30 genetic variants linked to age at menarche in Koreans.

Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.

Hyerim Shin … Hae Young Yoo

Journal of Korean biological nursing science · Nov 2025

Background

Age at menarche (age at menarche) is influenced by genetic and environmental factors and is associated with reproductive health outcomes.

Purpose

This study aimed to identify genetic variants associated with age at menarche in the Korean population through a genome-wide association study (genome-wide association study) and investigate the relationship between age at menarche and early menopause.

Methods

In total, 6,150,556 single nucleotide polymorphisms (single nucleotide polymorphisms) were generated from full genotyping data of the Health Examinee and Korea Association Resource cohorts, and analyses were conducted on 40,570 selected participants.

n = 40,570 selected participants

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Results

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Thirty gene variants were significantly linked to the age periods started, in this population.

n = 40,570 selected participants

More results

The most significant single nucleotide polymorphisms was rs314275 (beta = 0.0925, p = 2.74 × 10 -12 ) in the Lin-28 homolog B ( LIN28B ) gene and the single nucleotide polymorphisms with the largest effect estimate was rs67367692 (beta = 0.1238, p = 5.06 × 10 -8 ) in the matrix metallopeptidase 12 ( MMP12 ) gene.

More results

Individuals with a higher polygenic risk score for age at menarche showed an increased risk of early menopause.

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Conclusion · 1 of 2

Genetic determinants influence age at menarche and early menopause in the Korean population.

Conclusion · 2 of 2

These findings suggest that the genetic factors contributing to late menarche may also increase the risk of early menopause, highlighting the importance of considering genetic risks in women's health strategies.

Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.

Genetic heritability of age at menarche and its association with early menopause in the Korean population: a secondary data analysis.

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