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New research · Obstetrics & Gynecology
The New England journal of medicine · 23h
Randomized trialThe New England journal of medicine · 2025

Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer.

Hua Tu, He Huang, Yanfang Li … PHENIX Investigators
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Obstetrics & GynecologyRandomized trial

Sentinel-lymph-node biopsy alone is noninferior for disease-free survival in early-stage cervical cancer.

Sentinel-Lymph-Node Biopsy Alone or with Lymphadenectomy in Cervical Cancer.

Hua Tu et al. · The New England journal of medicine · 2025
Background

Limited data are available on survival outcomes after sentinel-lymph-node biopsy alone as compared with lymphadenectomy in cervical cancer.

Methods

Who had negative sentinel lymph nodes were intraoperatively assigned in a 1:1 ratio not to undergo pelvic lymphadenectomy (the biopsy-only group) or to undergo lymphadenectomy (the lymphadenectomy group).

n = 838 patients
Results

the chance of staying cancer-free for 3 years was higher with biopsy only

difference -2.30 (95% CI -5 to 0.50)
null = 0-50.50
CI crosses the null - not significant
More results

A total of 838 patients underwent randomization: 420 patients were assigned to the biopsy-only group and 418 to the lymphadenectomy group.

Retroperitoneal nodal recurrences occurred in no patients in the biopsy-only group and in 9 patients (2.2%) in the lymphadenectomy group.

“
Conclusion · 1 of 2

In patients with early-stage cervical cancer, sentinel-lymph-node biopsy alone was noninferior to lymphadenectomy with respect to disease-free survival and was associated with fewer complications.

Conclusion · 2 of 2

(Funded by Guangzhou Municipal Science and Technology and others; PHENIX ClinicalTrials.gov number, NCT02642471.).

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