Burden and temporal trends of cervical cancer in reproductive-age females from 1990 to 2021 and projections…

Cohort studyJournal of gynecologic oncology· Jul 2026

Burden and temporal trends of cervical cancer in reproductive-age females from 1990 to 2021 and projections to 2035 in G20 countries: a systematic analysis of the Global Burden of Disease Study 2021.

Xiangwen Li, Siyu Pan, Pengfei Qu … Li Song

Gynecologic CancerCohort studyClinical practiceQ1IF 3.8

Cervical cancer burden declined among G20 reproductive-age women from 1990 to 2021.

Burden and temporal trends of cervical cancer in reproductive-age females from 1990 to 2021 and projections to 2035 in G20 countries: a systematic analysis of the Global Burden of Disease Study 2021.

Xiangwen Li … Li Song

Journal of gynecologic oncology · Jul 2026 · Q1 in Obstetrics & Gynecology

Background

Cervical cancer remains a critical global health threat.

Purpose

This study aimed to characterize long-term cervical cancer burden trends and project future epidemiological trajectories among G20 reproductive-age females.

Methods

Using Global Burden of Disease 2021 data, we analyzed cervical cancer disability-adjusted life years (disability-adjusted life years) among females aged 15-49 years in G20 countries (1990-2021) via Joinpoint regression, health inequality indices, Das Gupta decomposition, and Bayesian age-period-cohort projection to 2035.

AAPC=-1.40%

Results

AAPC=-1.40%

cervical cancer death and disability fell overall across G20 women

More results

In 2021, cervical cancer generated 2.27 million disability-adjusted life years among G20 reproductive-age females, with age-standardized rates ranging from 24.89 (Saudi Arabia) to 667.65 (South Africa) per 100,000.

More results

Sociodemographic Index (Sociodemographic Index)-related inequality narrowed (1990: Slope Index of Inequality [SII]=-349.58, Concentration Index=-0.21; 2021: SII=-261.82, Concentration Index=-0.18), but persisted.

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Conclusion

Differentiated, evidence-based strategies tailored to national burden characteristics, addressing demographic shifts, key health system gaps, and human papillomavirus genotype disparities, are critically needed to successfully achieve the World Health Organization 2030 global cervical cancer elimination targets.

Burden and temporal trends of cervical cancer in reproductive-age females from 1990 to 2021 and projections to 2035 in G20 countries: a systematic analysis of the Global Burden of Disease Study 2021.

Burden and temporal trends of cervical cancer in reproductive-age females from 1990 to 2021 and projections to 2035 in G20 countries: a systematic analysis of the Global Burden of Disease Study 2021.

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