Biochemical pregnancy outcomes following dual versus human chorionic gonadotropin-only trigger in…

Cohort studyAnnals of Saudi medicine· 2026

Biochemical pregnancy outcomes following dual versus human chorionic gonadotropin-only trigger in gonadotropin-stimulated intrauterine insemination cycles for unexplained infertility: a retrospective cohort study.

Mehtap Akin Efe, Ozlem Dural, Hevra Ekin Ulusoy … Cemil Akgül

Maternal-Fetal MedicineCohort studyTreatmentQ3IF 1.6

Dual trigger not significantly associated with higher biochemical pregnancy odds versus hCG alone

Biochemical pregnancy outcomes following dual versus human chorionic gonadotropin-only trigger in gonadotropin-stimulated intrauterine insemination cycles for unexplained infertility: a retrospective cohort study.

Mehtap Akin Efe … Cemil Akgül

Annals of Saudi medicine · 2026 · Q3 in General Medicine

Background

Unexplained infertility remains a diagnostic and therapeutic challenge.

Purpose

To evaluate whether dual trigger improves biochemical pregnancy outcomes compared with hCG-only trigger in gonadotropin-stimulated intrauterine insemination cycles.

Methods

Single-center, tertiary referral center.

n = 96 patients

Results

no clear boost in pregnancy odds with dual trigger versus hCG alone

OR by subgroup · 95% CI

More results

Biochemical pregnancy occurred in 18.6% of the dual trigger group and 11.3% of the hCG-only group ( P =.315).

Subgroup analysis revealed a significant association between infertility duration and biochemical pregnancy ( P =.04), with 76.9% of conceptions occurring in women with 2-3 years of infertility.

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Conclusion · 1 of 2

Dual trigger did not significantly improve biochemical pregnancy rates compared with hCG-only trigger (OR=1.8, 95% CI: 0.6-5.6). Infertility duration was the only significant predictor of treatment success.

Conclusion · 2 of 2

Larger multi-center trials are required due to the current study's limited power. LIMITATIONS: Retrospective design, single-center setting, and limited sample size may restrict generalizability.

Biochemical pregnancy outcomes following dual versus human chorionic gonadotropin-only trigger in gonadotropin-stimulated intrauterine insemination cycles for unexplained infertility: a retrospective cohort study.

Biochemical pregnancy outcomes following dual versus human chorionic gonadotropin-only trigger in gonadotropin-stimulated intrauterine insemination cycles for unexplained infertility: a retrospective cohort study.

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