Mother-to-child HIV exposure and its relation with neurodevelopmental disorders: a systematic review and meta-analysis.

MCE children show not statistically significant neurodevelopmental outcomes in our meta-analysis. Heterogeneity in assessment tools and limited data on demographic and socioeconomic profile constrain definitive conclusions.

Further research addressing confounders is crucial for developing targeted interventions.

IMPACT: This study highlights growing evidence on mother-to-child exposure to HIV may have subtle to no neurodevelopmental differences when compared to their unexposed peers, but data are heterogeneous and conflicting.