Lymphocyte-C-Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in…

Cohort studyAnnals of gastroenterological surgery· May 2026

Lymphocyte-C-Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis.

Yuhki Koike, Koki Higashi, Yuki Sato … Yuji Toiyama

Pediatric Infection & VaccinationCohort studyPrognosisQ1IF 3.7

Low preoperative lymphocyte-to-CRP ratio predicts surgical site infection after pouch surgery in pediatric ulcerative colitis

Lymphocyte-C-Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis.

Yuhki Koike … Yuji Toiyama

Annals of gastroenterological surgery · May 2026

Background

Surgical site infection (surgical site infection) is a major complication after ileal pouch-anal anastomosis (ileal pouch-anal anastomosis) in pediatric ulcerative colitis (ulcerative colitis), significantly impairing quality of life.

Purpose

This study assessed the utility of preoperative LCR in predicting surgical site infection in pediatric ulcerative colitis.

Methods

We retrospectively reviewed pediatric ulcerative colitis patients who underwent ileal pouch-anal anastomosis at Mie University Hospital between 2000 and 2024.

n = 57 patients

Results

low lymphocyte-to-CRP ratio raises infection odds over sixfold

90.9%

Sensitivity

71.7%

Specificity

More results

Among 57 patients, 11 (19.3%) developed surgical site infection.

In both groups, preoperative LCR was significantly lower in surgical site infection-positive patients.

ROC analysis demonstrated good discrimination (AUC: 0.80), with an optimal cutoff of LCR < 5000 (sensitivity: 90.9%, specificity: 71.7%).

“

Conclusion · 1 of 2

Preoperative LCR is a simple, objective biomarker that reliably predicts surgical site infection risk in pediatric ulcerative colitis patients undergoing ileal pouch-anal anastomosis.

Conclusion · 2 of 2

Incorporating LCR into preoperative risk stratification may enable personalized interventions, including nutritional optimization and tailored prophylaxis, to improve surgical outcomes.

Lymphocyte-C-Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis.

Lymphocyte-C-Reactive Protein Ratio as Promising New Marker for Predicting Surgical Site Infection in Children With Ulcerative Colitis.

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