Development and Validation of a Predictive Model for Wheezing Illness Following Human Bocavirus 1 Infection in Children.

However, there is still a lack of effective clinical predictive indicators for wheezing illnesses in children infected with HBoV1.

Finally, a multivariate logistic regression model was constructed in a training dataset comprising 80% of patients and validated in an independent test dataset comprising 20% of patients.

Using a Youden-derived threshold (0.382), the high-risk group in the test set had an observed wheezing rate of 85.3%, compared with 18.7% in the low-risk group ( p < 0.001).

Calibration was satisfactory (Hosmer-Lemeshow p = 0.324 and 0.576).