Optimizing the Meropenem Dosing Regimen in Neonates: A Dual-Centre Cohort Study.

The analysis included 114 neonates.

Typical clearance and V d were 0.175 L·h⁻¹ and 0.403 L, respectively.

For the aggressive target (100% f T > MIC), TSPI often required high doses (≥30 mg·kg⁻¹ every 8 h).

Simulated steady-state peak concentrations increased with the bolus fraction; therefore, the 5 mg·kg⁻¹ bolus followed by infusion of the remaining 15 mg·kg⁻¹ was selected as the preferred OTAT regimen to limit unnecessary peak exposure.