Longitudinal Changes in Pulmonary Function After Treatment of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study.

Among 606 survivors at a median of 27.2 (range 11.3-54.0) years from diagnosis, abnormal FEV1, TLC, and DLCOcorr Z-scores were noted in 49.5%, 51.4%, and 38.0%, respectively.

Among those with ≥2 PFT assessments (n = 480), all Z-scores declined, most pronounced at ≥ 30-years from diagnosis.

Obesity was associated with declining FEV1 and TLC; Smoking status was associated with declining DLCOcorr Z-scores.

Worsening or persistently abnormal Z-scores for FEV1, TLC, and DLCOcorr were associated with decline in 6MWT distance and self-reported physical function.