A retrospective review of leprosy diagnosed histopathologically from skin biopsy specimens in central South Africa.

Leprosy persists as a sporadic but geographically widespread disease in central South Africa, often presenting in advanced multibacillary forms. Histopathology remains essential for diagnosis and subtyping.

Strengthening clinician awareness, biopsy protocols, and treatment continuity is critical to achieving the goal of zero leprosy of the World Health Organization.

CONTRIBUTION: The findings confirm that, although rare, leprosy still prevails in central South Africa.