Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma.

The carbon ion radiation therapy group also showed significantly reduced risks of local failure (5-year local failure rate 5.6% vs 13.4%, P = .025) and enucleation (5-year enucleation rate 8.5% vs 24.2%, P < .001).

Moreover, carbon ion radiation therapy was superior in terms of visual acuity preservation: the proportion of patients with visual acuity of ≥20/200 decreased from 64.7% initially to 23.7% at last follow-up in the carbon ion radiation therapy group and from 64.1% to 6.3% in the SABR group ( P = .005).