Post

New research · Ophthalmology
Advances in radiation oncology · 17h
Cohort studyAdvances in radiation oncology · 2025

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma.

Jina Kim, Masaru Wakatsuki, Shuri Aoki … Kyung Hwan Kim
Read paper
OphthalmologyCohort study

Carbon ion therapy was associated with better 5-year progression-free survival than photon SABR in choroidal melanoma.

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma.

Jina Kim … Kyung Hwan Kim
Advances in radiation oncology · 2025
Background

To our knowledge, no study has compared the treatment outcomes of carbon ion radiation therapy (carbon ion radiation therapy) and photon-based stereotactic ablative radiation therapy (SABR) in patients with choroidal melanoma.

Purpose

This study aimed to evaluate the treatment outcomes of patients with choroidal melanoma treated with carbon ion radiation therapy or photon-based SABR.

Methods

In the carbon ion radiation therapy group received a median of 70 Gy delivered in a median dosage of 14 Gy per fraction, and patients in the SABR group received a median of 60 Gy delivered in a median dosage of 15 Gy per fraction.

n = 346 patients
Results

carbon ion therapy kept the tumor from progressing more often over 5 years

69%
CIRT
56.5%
SABR
More results

The carbon ion radiation therapy group also showed significantly reduced risks of local failure (5-year local failure rate 5.6% vs 13.4%, P = .025) and enucleation (5-year enucleation rate 8.5% vs 24.2%, P < .001).

More results

Moreover, carbon ion radiation therapy was superior in terms of visual acuity preservation: the proportion of patients with visual acuity of ≥20/200 decreased from 64.7% initially to 23.7% at last follow-up in the carbon ion radiation therapy group and from 64.1% to 6.3% in the SABR group ( P = .005).

“
Conclusion

Carbon ion radiation therapy was found to be superior to SABR in patients with choroidal melanoma in terms of PFS, local control, and preservation of vision and eye.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment