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Cohort studyAdvances in radiation oncology · 2025

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma.

Jina Kim, Masaru Wakatsuki, Shuri Aoki … Kyung Hwan Kim

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OphthalmologyCohort study

Carbon ion therapy was associated with better 5-year progression-free survival than photon SABR in choroidal melanoma.

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma.

Jina Kim … Kyung Hwan Kim

Advances in radiation oncology · 2025

Background

To our knowledge, no study has compared the treatment outcomes of carbon ion radiation therapy (carbon ion radiation therapy) and photon-based stereotactic ablative radiation therapy (SABR) in patients with choroidal melanoma.

Purpose

This study aimed to evaluate the treatment outcomes of patients with choroidal melanoma treated with carbon ion radiation therapy or photon-based SABR.

Methods

In the carbon ion radiation therapy group received a median of 70 Gy delivered in a median dosage of 14 Gy per fraction, and patients in the SABR group received a median of 60 Gy delivered in a median dosage of 15 Gy per fraction.

n = 346 patients

Results

carbon ion therapy kept the tumor from progressing more often over 5 years

69%

CIRT

56.5%

SABR

More results

The carbon ion radiation therapy group also showed significantly reduced risks of local failure (5-year local failure rate 5.6% vs 13.4%, P = .025) and enucleation (5-year enucleation rate 8.5% vs 24.2%, P < .001).

More results

Moreover, carbon ion radiation therapy was superior in terms of visual acuity preservation: the proportion of patients with visual acuity of ≥20/200 decreased from 64.7% initially to 23.7% at last follow-up in the carbon ion radiation therapy group and from 64.1% to 6.3% in the SABR group ( P = .005).

“

Conclusion

Carbon ion radiation therapy was found to be superior to SABR in patients with choroidal melanoma in terms of PFS, local control, and preservation of vision and eye.

Post

Carbon Ion Versus Photon-based Stereotactic Ablative Radiation Therapy for Patients with Choroidal Melanoma.

Carbon ion therapy was associated with better 5-year progression-free survival than photon SABR in choroidal melanoma.

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