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Cohort studyEuropean journal of ophthalmology · 2026

Clinical characteristics and outcomes of secondary orbital lymphoma.

Trisha Yc Pecoraro, Kenny Y Wang, B Michelle Kim … Lauren A Dalvin

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OphthalmologyCohort study

Systemic lymphoma recurrence occurred in over half of patients with secondary orbital lymphoma.

Clinical characteristics and outcomes of secondary orbital lymphoma.

Trisha Yc Pecoraro … Lauren A Dalvin

European journal of ophthalmology · 2026

Purpose

To investigate the clinical features, treatments, and outcomes of patients with secondary orbital lymphoma.

Methods

Major Findings In this cohort of 31 patients, 15 (48.4%) were female and 27 (87.1%) were white.

n = 31 patients

Results

58.1%

systemic lymphoma returned in more than half of patients

n = 31 patients

More results

Follicular lymphoma was the most common subtype (n = 13, 41.9%) and was more associated with unilateral disease compared to other subtypes (p = 0.01).

Common presenting symptoms included a palpable mass (n = 17, 54.8%), eyelid swelling (n = 16, 51.6%), and ptosis (n = 12, 38.7%).

More results

Patients were most often diagnosed with Ann Arbor Stage IV lymphoma (n = 17, 54.8%) via incisional biopsy (n = 13, 41.9%).

Radiation therapy (n = 9, 29.0%) was the most common initial treatment, and most patients received radiation (n = 19, 61.3%) and/or chemotherapy (n = 21, 67.7%).

“

Conclusion · 1 of 2

Follicular lymphoma was the predominant subtype of secondary orbital lymphoma in this cohort.

Conclusion · 2 of 2

Most patients with secondary orbital lymphoma presented with advanced disease where few achieved complete remission and more than half of the patients developed systemic recurrence despite majority retaining visual acuity.

Post

Clinical characteristics and outcomes of secondary orbital lymphoma.

Systemic lymphoma recurrence occurred in over half of patients with secondary orbital lymphoma.

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