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New research · Ophthalmology
European journal of ophthalmology · 1d
Cohort studyEuropean journal of ophthalmology · 2026

Clinical characteristics and outcomes of secondary orbital lymphoma.

Trisha Yc Pecoraro, Kenny Y Wang, B Michelle Kim … Lauren A Dalvin
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OphthalmologyCohort study

Systemic lymphoma recurrence occurred in over half of patients with secondary orbital lymphoma.

Clinical characteristics and outcomes of secondary orbital lymphoma.

Trisha Yc Pecoraro … Lauren A Dalvin
European journal of ophthalmology · 2026
Purpose

To investigate the clinical features, treatments, and outcomes of patients with secondary orbital lymphoma.

Methods

Major Findings In this cohort of 31 patients, 15 (48.4%) were female and 27 (87.1%) were white.

n = 31 patients
Results
58.1%
systemic lymphoma returned in more than half of patients
n = 31 patients
More results

Follicular lymphoma was the most common subtype (n = 13, 41.9%) and was more associated with unilateral disease compared to other subtypes (p = 0.01).

Common presenting symptoms included a palpable mass (n = 17, 54.8%), eyelid swelling (n = 16, 51.6%), and ptosis (n = 12, 38.7%).

More results

Patients were most often diagnosed with Ann Arbor Stage IV lymphoma (n = 17, 54.8%) via incisional biopsy (n = 13, 41.9%).

Radiation therapy (n = 9, 29.0%) was the most common initial treatment, and most patients received radiation (n = 19, 61.3%) and/or chemotherapy (n = 21, 67.7%).

“
Conclusion · 1 of 2

Follicular lymphoma was the predominant subtype of secondary orbital lymphoma in this cohort.

Conclusion · 2 of 2

Most patients with secondary orbital lymphoma presented with advanced disease where few achieved complete remission and more than half of the patients developed systemic recurrence despite majority retaining visual acuity.

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