Post

New research · Ophthalmology
Cell communication and signaling : CCS · 2d
Animal / preclinicalCell communication and signaling : CCS · 2026

The IGF2-ERK-Fos axis drives a Müller cell glial-mesenchymal transition-like response to disrupt retinal homeostasis in early myopia.

Jiaojiao Feng, Xiaoqi Gong, Yibo Han … Hongsheng Bi
Read paper
OphthalmologyAnimal / preclinical

Retinal support cells expand sharply in early experimental myopia.

The IGF2-ERK-Fos axis drives a Müller cell glial-mesenchymal transition-like response to disrupt retinal homeostasis in early myopia.

Jiaojiao Feng … Hongsheng Bi
Cell communication and signaling : CCS · 2026
Background

Myopia is increasingly recognized as a complex pathology involving retinal remodeling, yet the cellular mechanisms linking early visual stress to this process remain unclear.

Purpose

This study investigated whether Müller glial (MG) cells undergo a glial-mesenchymal transition (glial-mesenchymal transition)-like response in early myopia and identified the upstream signaling axis driving this transformation.

18.9%
Results
18.9%
vs. 6.9%
Müller support cells made up nearly 3× more of retinal cells
More results

IGF2 signaling was elevated in myopic MG cells and correlated with ERK/Fos activation.

More results

In vivo siIGF2 attenuated myopia progression, preserved retinal function/structure, suppressed MG activation/proliferation and glial-mesenchymal transition/extracellular matrix marker expression, and reduced inner limiting membrane abnormalities and retinal stiffening.

“
Conclusion

The IGF2-ERK-Fos axis is a key upstream driver of this pathology, presenting a novel target for intervention to preserve retinal homeostasis.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
AI / Informatics
0·962 for OCT
MerMED-FM was very accurate at diagnosing diseases using eye scans
AI / Informatics
0.98
Artificial intelligence's eyelid-height measurements matched doctors' manual measurements almost perfectly
AI / Informatics
92.1%
combining eye scans and photos correctly told benign from cancerous lesions apart nearly every time
Cohort Study
28.6%
recurred locally in more than 1 in 4 patients over years of follow-up
Cohort Study
-0.395
excision group's post-op eyelid fullness score was lower - greater improvement
Cohort Study
86.7%
of infants probed after 12 months still had unresolved tear duct blockage
Observational
16%
eyelid tissue in rosacea patients showed less of this key repair-signaling protein inside cell nuclei
Cohort Study
25%
about 1 in 4 treated cases had symptoms return after improving