Post

New research · Ophthalmology
Cell communication and signaling : CCS · 2d
Animal / preclinicalCell communication and signaling : CCS · 2026

The IGF2-ERK-Fos axis drives a Müller cell glial-mesenchymal transition-like response to disrupt retinal homeostasis in early myopia.

Jiaojiao Feng, Xiaoqi Gong, Yibo Han … Hongsheng Bi
Read paper
OphthalmologyAnimal / preclinical

Retinal support cells expand sharply in early experimental myopia.

The IGF2-ERK-Fos axis drives a Müller cell glial-mesenchymal transition-like response to disrupt retinal homeostasis in early myopia.

Jiaojiao Feng … Hongsheng Bi
Cell communication and signaling : CCS · 2026
Background

Myopia is increasingly recognized as a complex pathology involving retinal remodeling, yet the cellular mechanisms linking early visual stress to this process remain unclear.

Purpose

This study investigated whether Müller glial (MG) cells undergo a glial-mesenchymal transition (glial-mesenchymal transition)-like response in early myopia and identified the upstream signaling axis driving this transformation.

18.9%
Results
18.9%
vs. 6.9%
Müller support cells made up nearly 3× more of retinal cells
More results

IGF2 signaling was elevated in myopic MG cells and correlated with ERK/Fos activation.

More results

In vivo siIGF2 attenuated myopia progression, preserved retinal function/structure, suppressed MG activation/proliferation and glial-mesenchymal transition/extracellular matrix marker expression, and reduced inner limiting membrane abnormalities and retinal stiffening.

“
Conclusion

The IGF2-ERK-Fos axis is a key upstream driver of this pathology, presenting a novel target for intervention to preserve retinal homeostasis.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cross-sectional
44.1%
had too much homocysteine in the blood, a far larger share than in dry AMD or healthy eyes
Cohort Study
92.3%
most laser-treated eyes had a favorable eye-structure outcome
Cohort Study
56%
lost three or more lines on the eye-chart vision test
Cohort Study
50%
older patients were more likely to lose three or more lines of vision
Study
81%
trials where mask air leaks were detected blowing toward the eyes
Cohort Study
13.5%
Central retinal artery peak blood-flow speed was 13.5% lower in diabetic patients.
Study
379 +/- 156 microm
lower thickness in the central retina, checked with an eye scan
Case Report
9 of 10 eyes
eyes had better measured vision after treatment