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StudyRadiological physics and technology · 2026

Dosimetric comparison of seed-less and multi-seed 125 I eye plaque: a Monte Carlo study.

Subhalaxmi Mishra, T Palani Selvam, Munir S Pathan, B K Sapra

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OphthalmologyStudy

Seed-less eye plaques retain more radiation dose at the tumor's deep edge than multi-seed plaques.

Dosimetric comparison of seed-less and multi-seed 125 I eye plaque: a Monte Carlo study.

Subhalaxmi Mishra … B K Sapra

Radiological physics and technology · 2026

Purpose

This study presents a comprehensive dosimetric comparison between Collaborative Ocular Melanoma Study (Collaborative Ocular Melanoma Study) eye plaque containing 125 I seeds and a novel seed-less design plaque of similar shape and radioactive strength using high-precision Monte Carlo Technique.

Results

seed-less design keeps more dose reaching the tumor's deep edge

23.7%

Seed-less

16.4%

Multi-seed

More results

Monte Carlo-based dose distributions such as central axis depth dose, lateral off-axis dose profiles and 2-dimensional isodose distributions for three different plaque diameters 10, 14 and 20 mm are calculated and compared with the dose distributions of analogous seed-less plaques.

More results

Seed-less plaque of 10 mm diameter produces comparable dose distribution with the corresponding multi-seed plaque design.

Seed-less plaques of 14 mm and 20 mm diameter deliver dose rates approximately twice as high as the corresponding multi-seed plaques.

“

Conclusion

By providing superior tumour dose uniformity and improved organs at risk protection, seed-less plaques represent a promising, dosimetrically superior alternative for management of large intraocular masses.

Post

Dosimetric comparison of seed-less and multi-seed 125 I eye plaque: a Monte Carlo study.

Seed-less eye plaques retain more radiation dose at the tumor's deep edge than multi-seed plaques.

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