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New research · Endocrinology
Journal of surgical case reports · 4d
Case reportJournal of surgical case reports · 2026

p16-Positive oropharyngeal squamous cell carcinoma metastasis to the thyroid following complete chemoradiotherapy response: a case report and review of the literature.

William H Cook, Anas A Linjawi, Veronika van Dijck
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EndocrinologyCase report

Thirteen of 22 lymph nodes were positive for metastatic oropharyngeal squamous cell carcinoma.

p16-Positive oropharyngeal squamous cell carcinoma metastasis to the thyroid following complete chemoradiotherapy response: a case report and review of the literature.

William H Cook … Veronika van Dijck
Journal of surgical case reports · 2026
Background

Metastasis of oropharyngeal squamous cell carcinoma (oropharyngeal squamous cell carcinoma) to the thyroid gland is rare, and p16-positive cases form an even smaller subset.

13/22
Results
13/22
13 of the 22 neck glands removed were found to contain cancer
More results

We present a case of p16-positive thyroid metastasis from oropharyngeal squamous cell carcinoma identified after complete treatment response.

Nine months after completing chemoradiotherapy, the patient developed throat pain and hoarseness.

More results

Computed tomography demonstrated an enlarged heterogeneous right thyroid gland and fine needle aspiration confirmed p16-positive metastatic oropharyngeal squamous cell carcinoma in the absence of locoregional recurrence.

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Conclusion

Further cases are required to better understand the epidemiology, optimal management, and prognosis of this presentation.

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