p16-Positive oropharyngeal squamous cell carcinoma metastasis to the thyroid following complete… | ScholarDeck

Paper

p16-Positive oropharyngeal squamous cell carcinoma metastasis to the thyroid following complete chemoradiotherapy response: a case report and review of the literature.

New research · Internal Medicine

Journal of surgical case reports · 1mo

Case reportJournal of surgical case reports· Jul 2026

p16-Positive oropharyngeal squamous cell carcinoma metastasis to the thyroid following complete chemoradiotherapy response: a case report and review of the literature.

William H Cook, Anas A Linjawi, Veronika van Dijck

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EndocrinologyCase reportQ3IF 0.5

Thirteen of 22 lymph nodes were positive for metastatic oropharyngeal squamous cell carcinoma.

p16-Positive oropharyngeal squamous cell carcinoma metastasis to the thyroid following complete chemoradiotherapy response: a case report and review of the literature.

William H Cook … Veronika van Dijck

Journal of surgical case reports · Jul 2026

Background

Metastasis of oropharyngeal squamous cell carcinoma (oropharyngeal squamous cell carcinoma) to the thyroid gland is rare, and p16-positive cases form an even smaller subset.

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Results

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13 of the 22 neck glands removed were found to contain cancer

More results

We present a case of p16-positive thyroid metastasis from oropharyngeal squamous cell carcinoma identified after complete treatment response.

Nine months after completing chemoradiotherapy, the patient developed throat pain and hoarseness.

More results

Computed tomography demonstrated an enlarged heterogeneous right thyroid gland and fine needle aspiration confirmed p16-positive metastatic oropharyngeal squamous cell carcinoma in the absence of locoregional recurrence.

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Conclusion

Further cases are required to better understand the epidemiology, optimal management, and prognosis of this presentation.

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