To investigate the therapeutic effect of recombinant tissue plasminogen activator (r-tPA) in patients with refractory toxic anterior chamber segment syndrome after cataract surgery with posterior chamber intraocular lens implantation.
Methods
This prospective cohort study was performed from May 2010 to November 2011 at a tertiary university-based medical centre.
n = 40 eyes
95%
Results
95%
had complete clearing of the fibrin buildup in the eye after one month
n = 40 eyes
More results
At 1 day after treatment, complete clearance of the fibrin reaction was observed in 32 patients (80%) and partial clearance in 8 (20%).
Mean visual acuity improved from 0.61±0.38 logMAR before treatment to 0.45±0.37 logMAR 1 month later (p=0.06).
More results
There were no statistically significant differences in improvement in visual acuity and fibrinolysis rate by time of r-tPA injection after surgery (10-15 days, n=16 vs 16-49 days, n=24).
There were no cases of increased intraocular pressure or endophthalmitis following the procedure.
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Conclusion
Intracameral injection of 25 µg r-tPA is safe and effective for the treatment of refractory fibrin reaction after cataract surgery.
