Intracameral recombinant tissue plasminogen activator (r-tPA) for refractory toxic anterior segment syndrome.

At 1 day after treatment, complete clearance of the fibrin reaction was observed in 32 patients (80%) and partial clearance in 8 (20%).

Mean visual acuity improved from 0.61±0.38 logMAR before treatment to 0.45±0.37 logMAR 1 month later (p=0.06).

There were no statistically significant differences in improvement in visual acuity and fibrinolysis rate by time of r-tPA injection after surgery (10-15 days, n=16 vs 16-49 days, n=24).

There were no cases of increased intraocular pressure or endophthalmitis following the procedure.