Comparison of Incidence of Respiratory Depression Between Ciprofol versus Propofol for Procedural Sedation…

Randomized trialDrug design, development and therapy· 2026

Comparison of Incidence of Respiratory Depression Between Ciprofol versus Propofol for Procedural Sedation During First-Trimester Surgical Abortion: A Randomized Controlled Trial.

Jing Chen, Ting Zhang, Conghui Zhang … Weidong Liang

Sedation & Anesthetic PharmacologyRandomized trialTreatmentQ1IF 6.0

Ciprofol caused less respiratory depression than propofol during first-trimester surgical abortion sedation

Comparison of Incidence of Respiratory Depression Between Ciprofol versus Propofol for Procedural Sedation During First-Trimester Surgical Abortion: A Randomized Controlled Trial.

Jing Chen … Weidong Liang

Drug design, development and therapy · 2026

Background

Respiratory depression remains a major safety concern during propofol-based sedation for surgical abortion.

Purpose

This randomized controlled trial aimed to compare the incidence of respiratory depression of ciprofol versus propofol, both combined with alfentanil, for procedural sedation in patients undergoing surgical abortion.

Methods

In this single-center, assessor-blinded, randomized controlled trial, 234 patients scheduled for surgical abortion under intravenous anesthesia were assessed for eligibility, and 226 were randomly assigned to receive either ciprofol (0.4 mg/kg; n=113) or propofol (2.0 mg/kg; n=113).

n = 234 patients

Results

ciprofol patients had dangerously slowed breathing needing airway help, fewer than with propofol

9.7%

Ciprofol

20.4%

Propofol

More results

The overall incidence of perioperative adverse events was lower in the ciprofol group (28.3% vs 64.6%, P < 0.001).

Injection pain was observed in 34.5% of patients receiving propofol and in none receiving ciprofol.

PONV, hemodynamic instability, procedure time, time to discharge, post-procedure pain scores and patient satisfaction were comparable between groups.

More results

No serious adverse events occurred.

“

Conclusion

Ciprofol combined with alfentanil was associated with a lower incidence of respiratory depression and perioperative adverse events than propofol, while providing comparable procedural sedation efficacy in patients undergoing surgical abortion.

Comparison of Incidence of Respiratory Depression Between Ciprofol versus Propofol for Procedural Sedation During First-Trimester Surgical Abortion: A Randomized Controlled Trial.

Comparison of Incidence of Respiratory Depression Between Ciprofol versus Propofol for Procedural Sedation During First-Trimester Surgical Abortion: A Randomized Controlled Trial.

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