Post

New research · Nephrology
Journal of the American Society of Nephrology : JASN · 1d
Cohort studyJournal of the American Society of Nephrology : JASN · 2026

Cardiovascular Risk Across Different Glomerular Diseases.

Luhua Jin, Jiao Liu, Caoxiang She … Sheng Nie
Read paper
NephrologyCohort study

Lupus nephritis is associated with a higher cardiovascular death risk.

Cardiovascular Risk Across Different Glomerular Diseases.

Luhua Jin et al. · Journal of the American Society of Nephrology : JASN · 2026
Background

It was well-established that patients with glomerulonephritis face an elevated cardiovascular risk, yet little was known about the differential impacts of various etiologies of glomerular disease on cardiovascular outcomes.

Purpose

In this large cohort study encompassing patients with distinct forms of glomerular nephritis, we aimed to compare the effects of different etiologies on cardiovascular death events.

Methods

Utilizing data from the China Renal Data System (CRDS) database, we identified 66,247 patients with glomerulonephritis across 14 distinct etiologies between 2000 and 2022.

Results
lupus nephritis patients have a cardiovascular death risk this many times higher than the general population
More results

Within a cohort of 66,247 patients with glomerulonephritis, immunoglobulin A (IgA) nephropathy (39%) was the most prevalent etiology, followed by lupus nephritis (17%) and membranous nephropathy (16%).

The overall crude cardiovascular death rates across glomerulonephritis subtypes ranged from 0.7 to 22.6 per 1,000 person-years.

More results

Furthermore, when compared directly to patients with minimal change disease, all other glomerulonephritis subtypes were associated with significantly greater cardiovascular death risk.

“
Conclusion

Patients with different underlying glomerular diseases exhibited markedly heterogeneous and elevated cardiovascular risk profiles.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cohort Study
hazard ratio 4.00
high genetic risk and severe CKM syndrome meant a much higher risk of knee arthritis
Cohort Study
11.1%
hospitalizations for heart inflammation in dialysis patients that included severe heart issues
Cohort Study
HR 4.00
Severe kidney scarring linked to about 4-fold higher rate of graft failure
Guideline
almost 30%
people with Von-Hippel Lindau syndrome are affected by kidney cancer
Cohort Study
14.0%
About 1 in 7 survivors without prior risk factors had persistent kidney damage
Guideline
“This consensus aims to clarify for which patients renal denervation may be a viable therapeutic option, identify the main clinical and procedural considerations for its implementation, and promote its optimal and safe use through appropriate patient selection and multidisciplinary evaluation.”
Cohort Study
-41.5 mg/dL
GLP-1 RAs were associated with lower total cholesterol
Guideline
approximately 80%
how many people with early AL amyloidosis are expected to live for 5 years