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New research · Nephrology
Journal of the American Society of Nephrology : JASN · 1d
Cohort studyJournal of the American Society of Nephrology : JASN · 2026

Cardiovascular Risk Across Different Glomerular Diseases.

Luhua Jin, Jiao Liu, Caoxiang She … Sheng Nie
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NephrologyCohort study

Lupus nephritis is associated with a higher cardiovascular death risk.

Cardiovascular Risk Across Different Glomerular Diseases.

Luhua Jin et al. · Journal of the American Society of Nephrology : JASN · 2026
Background

It was well-established that patients with glomerulonephritis face an elevated cardiovascular risk, yet little was known about the differential impacts of various etiologies of glomerular disease on cardiovascular outcomes.

Purpose

In this large cohort study encompassing patients with distinct forms of glomerular nephritis, we aimed to compare the effects of different etiologies on cardiovascular death events.

Methods

Utilizing data from the China Renal Data System (CRDS) database, we identified 66,247 patients with glomerulonephritis across 14 distinct etiologies between 2000 and 2022.

Results
lupus nephritis patients have a cardiovascular death risk this many times higher than the general population
More results

Within a cohort of 66,247 patients with glomerulonephritis, immunoglobulin A (IgA) nephropathy (39%) was the most prevalent etiology, followed by lupus nephritis (17%) and membranous nephropathy (16%).

The overall crude cardiovascular death rates across glomerulonephritis subtypes ranged from 0.7 to 22.6 per 1,000 person-years.

More results

Furthermore, when compared directly to patients with minimal change disease, all other glomerulonephritis subtypes were associated with significantly greater cardiovascular death risk.

“
Conclusion

Patients with different underlying glomerular diseases exhibited markedly heterogeneous and elevated cardiovascular risk profiles.

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