Complementary Role of Whole-Body MRI and CT in Hematologic Malignancies and Bone Marrow Disorders.

This clinical review provides a practical, scenario-based comparison of WBCT and whole-body MRI across diagnosis, staging, treatment response, and surveillance.

We emphasize real-world practical considerations, including scanner access, expertise, patient tolerance, radiation considerations, and cost.

Across all included disease categories, the broader pooled concordance estimate was 0.797 (95% CI: 0.667-0.885) with substantial heterogeneity reflecting variability in clinical context, reference standard, and protocol.

Whole-body MRI dominates in non-neoplastic marrow disorders where marrow characterization is essential.