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New research · Pathology
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 1d
Cohort studyEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026

The relationship of EBER, EGFR, p16, and E-cadherin expressions with epithelial-mesenchymal transition and tumor budding in laryngeal squamous cell carcinoma.

Özgecan Gündoğar, Sibel Bektaş, Pelin Akbaş, Fatih Tetik
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PathologyCohort study

EGFR positivity is associated with a substantially higher risk of aggressive laryngeal cancer.

The relationship of EBER, EGFR, p16, and E-cadherin expressions with epithelial-mesenchymal transition and tumor budding in laryngeal squamous cell carcinoma.

Özgecan Gündoğar et al. · European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
Purpose

The aim of this study was to determine the independent predictive value of these biomarkers in identifying the aggressive phenotype.

Methods

A total of 61 LSCC cases were included in this retrospective cohort study.

50.058-fold
Results
having EGFR makes the risk of aggressive laryngeal cancer substantially higher
More results

Tumor budding was detected in 54.1% of the cases, while EMT was observed in 37.7%.

Preservation of E-cadherin reduced the risk by 95% (OR: 0.049, p=0.016).

No independent association was found between EBER expression or TIL presence and the aggressive phenotype (p>0.05).

“
Conclusion · 1 of 2

This study demonstrates that a molecular signature characterized by EGFR and p16 positivity together with loss of E-cadherin identifies the most aggressive subgroup of LSCC patients, characterized by high-grade tumor budding and EMT.

Conclusion · 2 of 2

As the first study integrating this four-marker molecular panel with invasive tumor front parameters, our findings provide a novel prognostic perspective in laryngeal carcinogenesis.

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