Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An…

Cohort studyAmerican journal of ophthalmology· Jul 2026

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

Yi Stephanie Zhang, Celine Chaaya, Eric A Goldberg … IRIS® Registry Analytic Center Consortium

RetinaCohort studyClinical practiceQ1IF 4.2

Dexamethasone implants are associated with a higher rate of post-injection endophthalmitis.

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

Yi Stephanie Zhang … IRIS® Registry Analytic Center Consortium

American journal of ophthalmology · Jul 2026 · Q1 in Ophthalmology

Purpose

To evaluate the incidence of endophthalmitis after intravitreal injections using a large, national ophthalmic registry.

Methods

Retrospective clinical cohort study.

n = 10,000 cases

12

Results

12

per 10,000

a higher rate of eye infections after dexamethasone implant injections

n = 10,000 cases

More results

The rate of endophthalmitis was significantly higher for corticosteroid implants and pegcetacoplan compared to anti-VEGF injections.

“

Conclusion · 1 of 2

The incidence of post-injection endophthalmitis is greater with corticosteroid implants and anticomplement therapies.

Conclusion · 2 of 2

Heightened aseptic vigilance may be warranted with injections that necessitate larger gauge needles, modulate the immune response and/or are prepared from a vial.

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

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