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New research · Ophthalmology
American journal of ophthalmology · 1d
Cohort studyAmerican journal of ophthalmology · 2026

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

Yi Stephanie Zhang, Celine Chaaya, Eric A Goldberg … IRIS® Registry Analytic Center Consortium
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OphthalmologyCohort study

Dexamethasone implants are associated with a higher rate of post-injection endophthalmitis.

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

Yi Stephanie Zhang et al. · American journal of ophthalmology · 2026
Purpose

To evaluate the incidence of endophthalmitis after intravitreal injections using a large, national ophthalmic registry.

Methods

Retrospective clinical cohort study.

n = 10,000 cases
12
Results
per 10,000
a higher rate of eye infections after dexamethasone implant injections
n = 10,000 cases
More results

The rate of endophthalmitis was significantly higher for corticosteroid implants and pegcetacoplan compared to anti-VEGF injections.

“
Conclusion · 1 of 2

The incidence of post-injection endophthalmitis is greater with corticosteroid implants and anticomplement therapies.

Conclusion · 2 of 2

Heightened aseptic vigilance may be warranted with injections that necessitate larger gauge needles, modulate the immune response and/or are prepared from a vial.

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