Post

New research · Ophthalmology
American journal of ophthalmology · 1d
Cohort studyAmerican journal of ophthalmology · 2026

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

Yi Stephanie Zhang, Celine Chaaya, Eric A Goldberg … IRIS® Registry Analytic Center Consortium
Read paper
OphthalmologyCohort study

Dexamethasone implants are associated with a higher rate of post-injection endophthalmitis.

Comparative Endophthalmitis Rates of Anti-VEGF, Corticosteroid Implants and Anti-Complement Injections: An IRIS® Registry Analysis.

Yi Stephanie Zhang et al. · American journal of ophthalmology · 2026
Purpose

To evaluate the incidence of endophthalmitis after intravitreal injections using a large, national ophthalmic registry.

Methods

Retrospective clinical cohort study.

n = 10,000 cases
12
Results
per 10,000
a higher rate of eye infections after dexamethasone implant injections
n = 10,000 cases
More results

The rate of endophthalmitis was significantly higher for corticosteroid implants and pegcetacoplan compared to anti-VEGF injections.

“
Conclusion · 1 of 2

The incidence of post-injection endophthalmitis is greater with corticosteroid implants and anticomplement therapies.

Conclusion · 2 of 2

Heightened aseptic vigilance may be warranted with injections that necessitate larger gauge needles, modulate the immune response and/or are prepared from a vial.

Read paper
0 comments

No comments yet. Be the first.

Related papers

LatestFoundational
Cohort Study
median 9
optometry referrals contained more complete documentation for glaucoma
Study
71.27%
medical students' higher accuracy in identifying eye infections after artificial intelligence training
Cross-sectional
64%
most patients reported little difficulty with their eye injections
Cross-sectional
37%
Only 37% of primary care providers and endocrinologists correctly identified diabetic retinopathy status.
Randomized Trial
adjusted difference -4.97
Baduanjin exercise led to a better overall quality of life than routine care
Study
58.26%
Qwen-7B correctly found eye diseases in over half of cases without specific training
Case Report
24 months
the patient's eye cancer remained gone for this period after treatment
Study
Mean 184 vs. 137
Residents in subsidized programs performed more cataract surgeries as primary surgeon.