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New research · Pathology
European annals of otorhinolaryngology, head and neck diseases · 1d
GuidelineEuropean annals of otorhinolaryngology, head and neck diseases · 2026

REFCOR guidelines on the management of olfactory neuroblastoma: A formalized expert consensus.

V Gorzkowski, C Monnot, C Castain … C Rumeau
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PathologyGuideline

Olfactory neuroblastoma patients need at least 20 years of follow-up.

REFCOR guidelines on the management of olfactory neuroblastoma: A formalized expert consensus.

V Gorzkowski et al. · European annals of otorhinolaryngology, head and neck diseases · 2026
Background

Olfactory neuroblastoma (ONB) is a rare malignant tumor of the sinonasal tract.

Purpose

The objective of this study is to present an evidence-based synthesis of the recommendations of the French Expert Network of Rare ENT Cancers (REFCOR), published in 2022, concerning the diagnostic and therapeutic management of ONB.

Methods

These recommendations result from a multidisciplinary consensus based on a critical analysis of the literature and feedback from expert centers within a structured process.

at least 20years
Results
patients need this much follow-up because the cancer can come back many years later
More results

ONB accounts for 6% of sinonasal cancers, with no identified risk factors.

Diagnosis is based on CT and MRI of the paranasal sinuses and skull base, together with systemic disease staging.

Histopathological analysis requires specialized expertise, with Hyams histological grade as the main prognostic factor.

More results

The standard of care consists in surgical resection followed by adjuvant radiotherapy.

“
Conclusion

The REFCOR guidelines aim to standardize diagnosis and treatment for ONB, but require completion by discussion in a specialized multidisciplinary tumor board.

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