Accurate recognition of 7 low-grade sweat gland carcinomas requires integrative interpretation.
Low-Grade Sweat Gland Carcinomas: A Review-A CME Article.
Kim Harnisch et al. · The American Journal of dermatopathology · 2026
Background
Primary cutaneous adnexal carcinomas (PCACs) are rare and biologically heterogeneous neoplasms that present significant diagnostic and therapeutic challenges.
Purpose
To synthesize and critically appraise current evidence on the clinicopathological, immunophenotypic, and molecular hallmarks of the 7 PCAC entities and to translate this knowledge into practical diagnostic and management guidance for dermatopathologists and oncologists.
Methods
A narrative review of the English-language literature was conducted using PubMed/MEDLINE without date restriction.
Results
the distinct types of slow-growing skin cancers from sweat glands that need careful diagnosis
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Conclusion · 1 of 2
Accurate recognition of PCACs requires integrative interpretation of morphology, immunoprofiles, and molecular findings supported by deep, full-thickness biopsy.
Conclusion · 2 of 2
Awareness of entity-specific patterns reduces misdiagnosis, guides appropriate surgical margins, and informs the selective use of ancillary testing and targeted therapies.