Exosome-Loaded Zinc Sulfide Nanoparticles Therapy for Psoriasis: Immune Regulation and Skin Repair by Targeting IL-23/IL-17A-NF-κB Pathway.

Adipose mesenchymal stem cells (adipose mesenchymal stem cells) were cultured and characterized, exosomes were isolated and validated by flow cytometry and TEM.

ZnS NPs were synthesized, confirmed by XRD and TEM, and encapsulated into exosomes.

In vivo , EXO-ZnS NPs significantly attenuated psoriatic symptoms, and Severity Index scores, reduced inflammatory mediators (IL-23, IL-17a, TNF-α, MCP-1, NLRP3), mitigated oxidative stress, downregulated proliferative markers (Ki-67, MMP-9), and inhibited VEGF-mediated angiogenesis. collectively restored epidermal structure and improved skin architecture.