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New research · Endocrinology
Lipids in health and disease · 2d
Cohort studyLipids in health and disease · 2026

Association between the cholesterol-high-density lipoprotein-glucose index and new-onset stroke in middle-aged and older adults with depressive symptoms: a longitudinal cohort analysis.

Yishu Wen, Wei Zhang, Lanxiang Wu … Heqing Zheng
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EndocrinologyCohort study

Lower CHG index is associated with a sharply higher stroke rate in depressed adults.

Association between the cholesterol-high-density lipoprotein-glucose index and new-onset stroke in middle-aged and older adults with depressive symptoms: a longitudinal cohort analysis.

Yishu Wen et al. · Lipids in health and disease · 2026
Background

Depression is a global disease that significantly increases the risk of stroke.

Methods

A total of 5,138 participants aged 45 and above, who had depressive symptoms (CES-D score ≥ 10) at the baseline and had no history of stroke, were included.

n = 5,138 participants
Results

a 1-unit higher CHG index (below 5.59) more than doubles stroke risk

HR by subgroup · 95% CI
null = 1
new-onset stroke increased by 48%
1.48
stroke increased by 117%
2.17
More results

In the fully adjusted Cox model, for every 1-unit increase in the CHG index, the risk of new-onset stroke increased by 48% (HR = 1.48, 95% CI: 1.15-1.90, P = 0.003).

However, the restricted cubic spline analysis revealed a significant non-linear relationship (D1 test P = 0.005), with the inflection point occurring at a CHG index of 5.59.

More results

Multivariable logistic regression yielded a consistent significant association (OR = 1.53, 95% CI: 1.16-2.03, P = 0.003).

Subgroup analysis and multiple sensitivity analyses (quartile analysis, exclusion of early stroke events, median binary classification analysis) all supported the robustness of the main findings.

“
Conclusion · 1 of 2

Among middle‑aged and older Chinese adults with depressive symptoms, the CHG index shows a significant non-linear positive association with the risk of new-onset stroke, and the risk increases sharply when the index is below 5.59.

Conclusion · 2 of 2

The CHG index may serve as a potential indicator for the early risk of stroke in this high-risk population.

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