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New research · Psychiatry
Journal of psychosomatic research · 2d
ReviewJournal of psychosomatic research · 2026

Cardiovascular risks in psychiatric disorders and psychiatric risks in cardiovascular disorders: implications for prevention and clinical management - a large-scale umbrella review encompassing 76 meta-analyses.

Michele Fornaro, Chiara Di Lorenzo, Augusto Esposito, Davide Perona
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PsychiatryReview

Major depressive disorder is common in patients with heart failure.

Cardiovascular risks in psychiatric disorders and psychiatric risks in cardiovascular disorders: implications for prevention and clinical management - a large-scale umbrella review encompassing 76 meta-analyses.

Michele Fornaro et al. · Journal of psychosomatic research · 2026
Background

Psychiatric and cardiovascular disorders often co-occur, complicating their assessment and management.

Purpose

Psychiatric and cardiovascular disorders often co-occur, complicating their assessment and management.

Methods

Meta-analytic systematic reviews of observational studies documenting the prevalence, risk factors, and outcomes associated with the co-occurrence of cardiovascular and psychiatric disorders, indexed from inception through March.16.2026, and meeting established diagnostic criteria, were included.

n = 76 meta-analyses
Results
nearly half of people with a failing heart also experience depression
n = 76 meta-analyses
More results

We included 76 meta-analyses yielding 131 meta-analytic estimates.

Based on pre-existing meta-analytic evidence, 22/24 prevalence estimates (91.7%) met moderate/strong credibility criteria.

Strong credibility emerged for: orthostatic hypotension in Lewy body(58%;95%C.

More results

Several additional disorders were multimorbid in>5% of people, yet with a lower credibility rating.

“
Conclusion

The present study provides an atlas of cardiovascular and psychiatric multimorbidity across varying levels of credibility, reinforcing the need for an integrated, multidisciplinary approach to patient care and for more research on actionable risk/protective factors and outcomes.

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