Adverse drug reactions in geriatric psychiatry-retrospective cohort study of a 6-year period.
Coronary heart disease raised odds of adverse drug reactions in elderly psychiatric inpatients
Adverse drug reactions in geriatric psychiatry-retrospective cohort study of a 6-year period.
To investigate the frequency and characteristics of adverse drug reactions (adverse drug reactions) that occurred on the gerontopsychiatric ward of Hannover Medical School over a 6-year period.
Retrospective monocentric cohort study.
coronary heart disease nearly triples the odds of an adverse drug reaction
Six hundred thirty-four patient cases (mean age 76.6 ± 7.1 years; 67.2% female) were analysed.
In total, 92 adverse drug reactions in 56 patient cases were registered in the study population.
The overall adverse drug reactions prevalence, the adverse drug reactions prevalence upon hospital admission, and the adverse drug reactions prevalence during hospitalisation were 8.8%, 6.3%, and 4.9%, respectively.
The most frequent adverse drug reactions were extrapyramidal symptoms, alterations in blood pressure or heart rate, and electrolyte disturbances.
Type and prevalence of adverse drug reactions in the present study were largely in accordance with previous reports. By contrast, we did not observe a relationship between advanced age or female sex and adverse drug reactions occurrence.
We detected a risk signal for cardiopulmonary adverse drug reactions related to general anaesthesia in the context of electroconvulsive therapy that warrants further investigation.
Elderly psychiatric patients should be carefully screened for cardiopulmonary comorbidities before initiation of electroconvulsive therapy.