Neurophysiological Signatures of Negative Symptom Improvement After High-Definition Transcranial Direct Current Stimulation: A Transcranial Magnetic Stimulation-Electroencephalography Study.

At baseline, patients showed reduced N100 amplitudes compared with controls (p = 0.005), which correlated with negative symptom severity (r = -0.28, p = 0.025).

These improvements were accompanied by N100 normalization (p = 0.013), and N100 changes were specifically associated with negative symptom improvement (p = 0.01), but not other symptom domains.