Esketamine for Postoperative Anxiety After Major Abdominal Tumor Surgery: A Randomized Clinical Trial.

The secondary outcomes showed that HAMA scores were similar between groups at POD3 (median [IQR], 6 [3-10] vs 7 [4-11]; adjusted mean difference, 0; 95% CI, -2 to 1; P = 0.59) and at POD30 (5 [3-8] vs 7 [4-11]; adjusted mean difference, -1; 95% CI, -3 to 1; P = 0.28).

Patients in the esketamine group also demonstrated lower scores for depressive symptoms on POD30 (median [IQR], 5 [2-8] vs 6 [3-10]; adjusted mean difference, -2; 95% CI, -3 to -1; P = 0.001).