Influence of Oliceridine on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients…

Randomized trialJournal of investigative surgery : the official journal of the Academy of Surgical Research· Dec 2026

Influence of Oliceridine on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients Stratified Using Apfel Score After General Anesthesia: A Prospective, Randomized Controlled Clinical Study.

Xinyang Heng, Aina Xu, Yajing Xiong … Jiangfeng Zhao

Perioperative MedicineRandomized trialTreatmentQ2IF 4.1

Oliceridine cut postoperative vomiting versus fentanyl in high-risk surgery patients

Influence of Oliceridine on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients Stratified Using Apfel Score After General Anesthesia: A Prospective, Randomized Controlled Clinical Study.

Xinyang Heng … Jiangfeng Zhao

Journal of investigative surgery · Dec 2026

Background

As a typical complication, postoperative nausea and vomiting (postoperative nausea and vomiting) usually occurs among patients undergoing general anesthesia surgery, diminishing postoperative satisfaction and recovery.

Purpose

Herein, we applied a new G-protein-biased μ-opioid receptor agonist, oliceridine, to compare its management with fentanyl on postoperative nausea and vomiting among high-risk patients receiving general anesthesia with transversus abdominis plane block (TAP).

Methods

In this prospective, double-blind, randomized controlled study, a total of 280 patients were enrolled for general anesthesia surgery, including laparoscopic cholecystectomy and laparoscopic gynecological surgery.

n = 280 patients

24.3%

Results

24.3%

versus 6.5%

vomiting occurred far less often with oliceridine than fentanyl

n = 280 patients

More results

In addition, the postoperative nausea visual analogue scale score showed significantly lower in the oliceridine group compared with the fentanyl group (1.40 ± 1.31 versus 2.01 ± 1.79, p = 0.013), accompanied by reduced rescue antiemetic rate (17.1% versus 7.2%, p = 0.011), with stable hemodynamic condition and comparable postoperative recovery.

“

Conclusion

DISCUSSION: According to our study, oliceridine may be a viable substitute for general anesthesia to ameliorate postoperative incidence of postoperative nausea and vomiting, along with its impressive pain control during anesthesia induction and maintenance.

Influence of Oliceridine on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients Stratified Using Apfel Score After General Anesthesia: A Prospective, Randomized Controlled Clinical Study.

Influence of Oliceridine on the Incidence of Postoperative Nausea and Vomiting in High-Risk Patients Stratified Using Apfel Score After General Anesthesia: A Prospective, Randomized Controlled Clinical Study.

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