Transurethral Ropivacaine (100 mg) Bladder Irrigation Reduces the Incidence of Bladder Discomfort in…

Randomized trialAnnals of African medicine· Jul 2026

Transurethral Ropivacaine (100 mg) Bladder Irrigation Reduces the Incidence of Bladder Discomfort in Transurethral Resection of Bladder Tumor: A Randomized Double-blind Trial.

Rajeev Ranjan, Atul Kumar Singh, Sumit Sachan … Amal Bhargavan

Regional AnesthesiaRandomized trialTreatmentQ3IF 1.0

Ropivacaine bladder irrigation cut catheter-related bladder discomfort after tumor resection

Transurethral Ropivacaine (100 mg) Bladder Irrigation Reduces the Incidence of Bladder Discomfort in Transurethral Resection of Bladder Tumor: A Randomized Double-blind Trial.

Rajeev Ranjan … Amal Bhargavan

Annals of African medicine · Jul 2026 · Q3 in General Medicine

Background

Catheter-related bladder discomfort (catheter-related bladder discomfort) is frequent after transurethral resection of bladder tumor (transurethral resection of bladder tumor) and adversely affects early recovery.

Methods

In this prospective, double-blind, randomized controlled trial, 162 adults undergoing transurethral resection of bladder tumor under spinal anesthesia were allocated to receive bladder irrigation with either 100 mL of 0.1% ropivacaine (100 mg) or 100 mL of saline for 10 min immediately after surgery.

n = 162 adults

Results

nearly half of ropivacaine patients had no bladder discomfort, versus about a third with saline

Ropivacaine (PACU CRBD

49.4%

Saline (PACU CRBD-free

34.6%

More results

Baseline characteristics were similar between groups.

At 24 h, 96.3% of patients in the ropivacaine group were catheter-related bladder discomfort-free compared with 87.7% in the control group (difference: 8.6%, 95% CI: 0.1-17.1).

Pain scores were lower with ropivacaine at 3-5 h (all P < 0.001).

More results

Hemodynamic variables remained stable in both groups, and no severe adverse events occurred.

“

Conclusion · 1 of 2

Intravesical ropivacaine 100 mg given as irrigation at the end of transurethral resection of bladder tumor significantly reduced immediate postoperative catheter-related bladder discomfort, lowered early pain scores, decreased the need for rescue analgesia, and improved short-term satisfaction without additional safety concerns.

Conclusion · 2 of 2

This simple and inexpensive intervention may be considered as part of enhanced recovery protocols in urological surgery.

Transurethral Ropivacaine (100 mg) Bladder Irrigation Reduces the Incidence of Bladder Discomfort in Transurethral Resection of Bladder Tumor: A Randomized Double-blind Trial.

Transurethral Ropivacaine (100 mg) Bladder Irrigation Reduces the Incidence of Bladder Discomfort in Transurethral Resection of Bladder Tumor: A Randomized Double-blind Trial.

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