Effect of Intravenous Magnesium on Postoperative Pain and Analgesic Outcomes in Patients Undergoing General Anesthesia: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Intravenous magnesium was associated with reduced postoperative pain, particularly at 24 h, and with opioid-sparing effects.

However, substantial heterogeneity across outcomes and generally low-to-moderate certainty of evidence warrant cautious interpretation. Magnesium may be considered as part of multimodal analgesia in appropriately selected patients.