Impact of propofol-based vs. volatile-based anaesthesia on survival and recurrence after cancer surgery: a systematic review and meta-analysis of randomised trials.

There was no significant effect on mortality (relative risk 1.03, 95%CI 0.94-1.13, p = 0.48).

Similar results were found for recurrence (relative risk 0.92, 95%CI 0.76-1.12, p = 0.41).

There was minimal detected heterogeneity in all analyses.

DISCUSSION: Propofol-based and volatile-based anaesthesia yield similar long-term oncological outcomes, with no significant differences in survival or recurrence and minimal heterogeneity, supported by high-certainty evidence.