Comparative efficacy and safety of ciprofol and propofol in hysteroscopy: A systematic review and…

Meta-analysisJournal of anaesthesiology, clinical pharmacology· 2026

Comparative efficacy and safety of ciprofol and propofol in hysteroscopy: A systematic review and meta-analysis of randomized controlled trials.

Ahmed Ayman Hafez, Mohamed S A Ahmed, Mohamed Attia Elfadali … Amir Hegazi

Sedation & Anesthetic PharmacologyMeta-analysisTreatmentQ2IF 1.0

Ciprofol lowers odds of hypoxemia during hysteroscopic sedation compared with propofol

Comparative efficacy and safety of ciprofol and propofol in hysteroscopy: A systematic review and meta-analysis of randomized controlled trials.

Ahmed Ayman Hafez … Amir Hegazi

Journal of anaesthesiology, clinical pharmacology · 2026 · Q2 in Anesthesiology

Background

Hysteroscopy is a common gynecological procedure requiring reliable sedation to ensure patient comfort during cervical dilation and endometrial manipulation.

Purpose

This meta-analysis aims to compare the clinical effectiveness and risk profile of ciprofol with those of propofol in hysteroscopic sedation.

Methods

We included randomized controlled trials that compared ciprofol with propofol for sedation during hysteroscopy.

n = 1,768 patients

OR = 0.34

Results

OR = 0.34

ciprofol cuts hypoxemia risk sharply versus propofol during sedation

n = 1,768 patients

More results

Six trials involving 1,768 patients (882 ciprofol; 886 propofol) met inclusion criteria.

Ciprofol provided equivalent efficacy and similar induction and recovery times.

It correlated with a decrease in the incidence of pain during injection (mean difference (MD) = O.

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Conclusion · 1 of 2

Ciprofol matches propofol's performance while reducing key adverse effects, making it a potentially safer option for older or medically fragile patients.

Conclusion · 2 of 2

Larger multicenter trials and cost-effectiveness studies are needed to guide clinical practice.

Comparative efficacy and safety of ciprofol and propofol in hysteroscopy: A systematic review and meta-analysis of randomized controlled trials.

Comparative efficacy and safety of ciprofol and propofol in hysteroscopy: A systematic review and meta-analysis of randomized controlled trials.

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