The Optimal Lung Cancer Ct Screening Strategy: A Cost-Effectiveness Study Incorporating Nelson Evidence, Evolving Cost of Treatment and Smoking Cessation Interventions.

1080 strategies are evaluated using the MISCAN-Lung microsimulation model, calibrated to NELSON and NLST data.

Risk-based recruitment (PLCOm2012) is more efficient than pack-year-based criteria.

Population-wide, lung cancer mortality would be reduced by 10.8% (1072 cases/year) at full uptake, or by 6.2% at 50% uptake.

For the first three years, at 50% uptake of screening, the strategy requires a 16.1% increase of national CT volume.