Metabolomic patterns in fatal carbon monoxide poisoning: A forensic toxicology perspective. | ScholarDeck

Paper

Metabolomic patterns in fatal carbon monoxide poisoning: A forensic toxicology perspective.

New research · Preventive Medicine

Forensic science international · 3w

StudyForensic science international· Dec 2025

Metabolomic patterns in fatal carbon monoxide poisoning: A forensic toxicology perspective.

Wilmar Alexander Ariza-Garcia, Daniel Pardo-Rodriguez, Gonzalo Taborda-Ocampo … Mónica P Cala

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Undersea & Hyperbaric MedicineStudyDiagnosisQ1IF 2.6

Carnitine 18:2 blood levels strongly distinguish fatal CO poisoning from controls.

Metabolomic patterns in fatal carbon monoxide poisoning: A forensic toxicology perspective.

Wilmar Alexander Ariza-Garcia … Mónica P Cala

Forensic science international · Dec 2025

Background

Carbon monoxide (CO) poisoning remains a major forensic and public health concern due to its high lethality and diagnostic challenges.

AUC = 0.846

Results

AUC = 0.846

AUC scale: 1.0 is perfect, 0.5 is chance; 0.846 shows strong discrimination.

More results

Integrated metabolomic and lipidomic analyses revealed significant dysregulation in lipid-related pathways, including steroid biosynthesis, mitochondrial β-oxidation, fatty acid and sphingolipid metabolism, and lysophospholipid-mediated membrane destabilization.

More results

Impaired biosynthesis of highly unsaturated fatty acids (highly unsaturated fatty acids) was also observed, potentially compromising membrane structure and signaling.

These findings highlight widespread metabolic disruption affecting energy homeostasis and lipid signaling.

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Conclusion

These results underscore the systemic metabolic impact of CO toxicity and support the continued exploration and implementation of targeted lipidomics as alternative forensic biomarkers in fatal poisonings.

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