Metabolomic patterns in fatal carbon monoxide poisoning: A forensic toxicology perspective.

Integrated metabolomic and lipidomic analyses revealed significant dysregulation in lipid-related pathways, including steroid biosynthesis, mitochondrial β-oxidation, fatty acid and sphingolipid metabolism, and lysophospholipid-mediated membrane destabilization.

Impaired biosynthesis of highly unsaturated fatty acids (highly unsaturated fatty acids) was also observed, potentially compromising membrane structure and signaling.

These findings highlight widespread metabolic disruption affecting energy homeostasis and lipid signaling.