Blood Pressure Reduction Time Windows in Stroke: A Systematic Review and Network Meta-Analysis.
Prehospital blood pressure reduction linked to higher mortality in ischemic stroke
Blood Pressure Reduction Time Windows in Stroke: A Systematic Review and Network Meta-Analysis.
The optimal time windows for blood pressure reduction (blood pressure reduction) treatment in patients with stroke remain controversial.
A systematic review of randomized controlled trials was conducted using PubMed, Embase, Cochrane Central Register of Controlled Trials, and Web of Science from their inception to March 21, 2026.
prehospital blood pressure lowering raised death risk in ischemic stroke
In intracerebral hemorrhage (intracerebral hemorrhage) patients (13 randomized controlled trials, n = 6826) and unspecified stroke patients (13 randomized controlled trials, n = 13,323), blood pressure reduction therapy had no significant impact on mortality at any time window.
Subgroup analyses were consistent with the primary findings.
This network meta-analysis suggests a potential association between prehospital blood pressure reduction treatment and increased risk of stroke mortality in ischemic stroke patients versus the reference and within 48 h blood pressure reduction groups, although evidence confidence is limited.
These findings support cautious prehospital blood pressure reduction use pending stroke subtype confirmation and highlight the need for further high-quality studies.