Opioid use disorder and hospital readmission in the United States from 2010 to 2022: Primary reasons and the…

Cohort studyDrug and alcohol dependence· Jun 2026

Opioid use disorder and hospital readmission in the United States from 2010 to 2022: Primary reasons and the complex interplay of comorbid conditions.

Fares Qeadan, Rose Thornquist, Ashlie McCunn … Sunday Azagba

Addiction MedicineCohort studyQ1IF 3.6

Secondary opioid use disorder linked to higher readmission risk after cardiovascular disease hospitalization

Opioid use disorder and hospital readmission in the United States from 2010 to 2022: Primary reasons and the complex interplay of comorbid conditions.

Fares Qeadan … Sunday Azagba

Drug and alcohol dependence · Jun 2026

Background

The opioid epidemic in the United States (U.

Purpose

This study examines how opioid use disorder (opioid use disorder), when not the primary diagnosis, influences the risk of hospital readmission among other primary health condition groups.

Methods

This retrospective study used data from the Nationwide Readmissions Database (Nationwide Readmissions Database) from 2010 to 2022.

Results

Patients with secondary opioid use disorder had about 10% higher risk of readmission after cardiovascular disease.

aRR 1.10 (95% CI 1.07 to 1.14)

CI excludes the null - significant

More results

The risk of RD-specific and CP-specific readmission was significantly higher for patients with secondary opioid use disorder than those without.

For all years and PHCs besides other SUDs, secondary opioid use disorder was associated with significantly higher risk of substance use disorder-specific readmission.

“

Conclusion · 1 of 2

Secondary opioid use disorder was differentially associated with hospital readmission across PHCs, with added risk when accompanied by select comorbidities.

Conclusion · 2 of 2

Findings support condition-tailored discharge planning, opioid use disorder treatment linkage, addiction consultation, peer navigation, and post-discharge follow-up.

Opioid use disorder and hospital readmission in the United States from 2010 to 2022: Primary reasons and the complex interplay of comorbid conditions.

Opioid use disorder and hospital readmission in the United States from 2010 to 2022: Primary reasons and the complex interplay of comorbid conditions.

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