Corrected count increment as a predictor of early graft dysfunction and mortality following living donor…

Cohort studyTransfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine· Jun 2026

Corrected count increment as a predictor of early graft dysfunction and mortality following living donor liver transplantation.

Deepti Sachan, Amal F Sam, Lavanya Sree B … Mohamed Rela

Transplant SurgeryCohort studyPrognosisQ3IF 1.1

Early graft dysfunction strongly predicts poor platelet transfusion response after living donor liver transplantation

Corrected count increment as a predictor of early graft dysfunction and mortality following living donor liver transplantation.

Deepti Sachan … Mohamed Rela

Transfusion clinique et biologique · Jun 2026 · Q3 in General Medicine

Background

Thrombocytopenia is prevalent in living donor liver transplantation (living donor liver transplantation), resulting from underlying liver disease and perioperative factors.

Purpose

This study evaluated the prevalence and severity of thrombocytopenia, platelet transfusion practices, assessed post-transfusion response using corrected count increment (corrected count increment), and predictors of poor corrected count increment in adult living donor liver transplantation recipients.

Methods

This prospective observational study was conducted at a quaternary care center after ethical committee approval.

n = 23 patients

Results

graft dysfunction on day 7 sharply raises the odds of poor platelet response

OR 10.20 (95% CI 2.40 to 43.10)

null 1

2.40

43.10

CI excludes the null - significant

More results

Among 100 living donor liver transplantation recipients (median age 52 years; 88% male), preoperative thrombocytopenia was observed in 91% of patients (17% severe).

Postoperatively, 66 platelet transfusions were given to 23 patients, with a mean corrected count increment of 9.0×10 9 /L.

More results

Poor corrected count increment was observed in 10 patients and was associated with higher bilirubin levels, prolonged INR, longer ICU stay, and increased 30-day mortality.

An absolute platelet count ≤71,000/mm 3 on day 7 predicted early allograft dysfunction with 85% sensitivity (AUC 0.79).

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Conclusion · 1 of 2

Thrombocytopenia is highly prevalent in living donor liver transplantation recipients.

Conclusion · 2 of 2

Poor corrected count increment is associated with graft dysfunction and adverse outcomes, suggesting that corrected count increment monitoring may help to prognosticate and anticipate worser outcomes.

Corrected count increment as a predictor of early graft dysfunction and mortality following living donor liver transplantation.

Corrected count increment as a predictor of early graft dysfunction and mortality following living donor liver transplantation.

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