Polymicrobial Bacteriobilia Is Associated with 90-Day Mortality After Pancreaticoduodenectomy.

Cohort studyRevista do Colegio Brasileiro de Cirurgioes· 2026

Polymicrobial Bacteriobilia Is Associated with 90-Day Mortality After Pancreaticoduodenectomy.

Philipe Franco do Amaral Tafner, Fernando Girardi da Silva, Alice Lily Carranza Cunha … Everton Cazzo

Read paper

Hepatobiliary & Pancreatic SurgeryCohort studyQ3IF 1.1

Polymicrobial bile cultures are associated with higher 60- and 90-day mortality after pancreaticoduodenectomy

Polymicrobial Bacteriobilia Is Associated with 90-Day Mortality After Pancreaticoduodenectomy.

Philipe Franco do Amaral Tafner … Everton Cazzo

Revista do Colegio Brasileiro de Cirurgioes · 2026 · Q3 in Surgery

Background

Bacteriobilia is common in patients undergoing pancreaticoduodenectomy (pancreaticoduodenectomy), particularly after preoperative biliary drainage.

Purpose

This study evaluated the association between intraoperative bile cultures and early postoperative outcomes following pancreaticoduodenectomy for periampullary tumors.

Methods

This retrospective cohort study included 176 patients who underwent pancreaticoduodenectomy with intraoperative bile culture between 2013 and 2024 at a tertiary center.

n = 176 patients

Results

Polymicrobial bile cultures more than doubled the odds of death by 60 days, after adjustment

OR by subgroup · 95% CI

More results

Bacteriobilia was detected in 146 patients (83%), with 70% presenting polymicrobial cultures.

Preoperative ERCP (OR 23.48; 95% CI 6.47-85.22; p<0.001) and biliary stent placement (OR 8.78; 95% CI 1.98-38.86; p=0.004) independently predicted bacteriobilia.

More results

Overall mortality was 12.5% at 30 days, 16.0% at 60 days, and 16.5% at 90 days.

Bacteriobilia per se was not associated with increased major morbidity or mortality.

“

Conclusion · 1 of 2

Although bacteriobilia is highly prevalent after preoperative biliary drainage, it does not independently worsen perioperative outcomes.

Conclusion · 2 of 2

Polymicrobial bile cultures were associated with increased 60- and 90-day mortality and may identify a subgroup of patients with greater biological and perioperative complexity, highlighting the importance of microbiological stratification and extended mortality assessment after pancreaticoduodenectomy.

Polymicrobial Bacteriobilia Is Associated with 90-Day Mortality After Pancreaticoduodenectomy.

Polymicrobial Bacteriobilia Is Associated with 90-Day Mortality After Pancreaticoduodenectomy.

Related papers